Enabling large scale genomic screening

ScreeninC provides clinical and basic research groups access to expertise in large-scale screening and unique research tools with the aim to expand and accelerate ongoing research programs that will increase our understanding of cancer and could yield new treatment options.

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We provide support for

1. Model generation

From well-established cancer cell lines to complex models including iPSC and genome-editing

2. Assay development

Cell-based assays for proliferation and viability, reporters with plate reader or FACS-based readout, and high-content imaging.

3. Screens

Pooled and arrayed platforms for CRISPR, CRISPRi, CRISPRa, RNAi and small molecule compounds libraries.

4. Data analysis

Application of the latest methods and tools to identify high-confidence hits in large screening datasets.

News & events

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Paradoxical activation of oncogenic signaling as a cancer treatment strategy

Pre-print available today!

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Systematic screening identifies ABCG2 as a critical factor underlying synergy of kinase inhibitors

New publication online today!

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Our core group

Amsterdam

Amsterdam

The NKI Robotics and Screening Center at the Netherlands Cancer Institute has extensive experience with the design, optimization and execution of pooled and arrayed screens across different platforms, including CRISPR, RNAi and chemical libraries.

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Groningen

Groningen

The iPSC/CRISPR centre at the European Research Institute for the Biology of Ageing (ERIBA) / University Medical Center Groningen has extensive experience with the generation and differentiation of iPSC models, and generation of reporter assays and execution of CRISPR screens.

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Leiden

Leiden

The Cell Observatory at the Leiden Academic Centre for Drug Research (LACDR) / Leiden University has extensive experience with high-throughput, high-content imaging and phenotypic screens based on fluorescent biosensors and GFP tagging approaches.

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